Tuesday, 19 November 2013

Immupharma is on the fast-track to success

Fast-track: Immupharma's anti-Lupus drug Lupuzor has been fast tracked for approval by the US Food and Drug AdministrationThe five-year chart reveals in 2009 it was trading comfortably above ?1 - a price that possibly over-stated its prospects at that time.
Equally, the fall below 37p in July almost certainly undervalued its potential and that of its lead product, Lupuzor, for the treatment of the auto-immune disease Lupus.
 Fast-track: Immupharma's anti-Lupus drug Lupuzor has been fast tracked for approval by the US Food and Drug Administration
Fast-track: Immupharma's anti-Lupus drug Lupuzor has been fast tracked for approval by the US Food and Drug Administration
A drug with blockbuster potential, it has been substantially de-risked and carries with it 'fast track' approval and a highly valued special protocol assessment (SPA) from the US Food & Drug Administration (FDA).

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This SPA has recently been upgraded by the FDA due to the important efficacy profile of the compound.
In summary, this will shorten the time of the trial, reduce the number of patients required to be in the trial and ultimately reduce the costs involved in the Phase III trial.
This means that so long as the same trial protocols are adhered to from the successful Phase IIb trial, the FDA will not require any further trials to be conducted. 
This is a key differentiator as it means the drug has a cheap fast track to market.
The more than doubling of ImmuPharma's value between July and late September this year (it hit a high of 77.5p), would suggest the market is cottoning on to the company's real worth, although dealers report the rebound was aided by the clearing of a significant stock overhang taken up by new international investors.
If this is the case, the investor or institution that dumped the stock could come to rue that decision, with City broker Panmure Gordon suggesting ImmuPharma is worth 150p a share.
In setting that target, analyst Savvas Neophytou cautioned: 'We believe investors should be patient and expect significant share price volatility in the coming weeks but, ultimately, from a purist valuation point of view, ImmuPharma shares are worth significantly more than the current share price.' 
IMMUPHARMA AT A GLANCE
AIM code: IMM
Value: ?52mln
Current price: 63p
Year-high: 77p
Low:34.5p
Clarity over the future of Lupuzor would undoubtedly act as a major share price catalyst, though sentiment may not have been helped by chief executive Dimitri Dimitriou's strategy to exploit the full potential of its lead drug.
The tradition in the sector is that an R&D group that has taken a drug to the cusp of phase III clinical trials goes out and looks for an industry partner with pockets deep enough to take it through the expensive final stage of scrutiny.
And, indeed, this is just what ImmuPharma is doing.
But it is running a parallel process where ImmuPharma will develop the drug itself.
And thanks to a ?50 million equity funding facility agreed with Darwin Strategic it has the financial muscle to follow through, should the company wish to use part of this facility.
It is a wily strategy that doesn't leave ImmuPharma relying on the outcome of talks with big pharma, but is one that has given certain commentators the jitters.
They have questioned whether industry appetite is there for Lupuzor but have neglected to assess the huge value that would be created by ImmuPharma taking the treatment all the way itself.
The appointment of Torreya Partners, a mergers, acquisitions and licensing specialist with offices in New York and London, to assist with the talks may assuage some of these concerns, and it perhaps points to where ImmuPharma is headed.
Panmure's Neophytou observed: "Success in licensing discussions is not guaranteed but this appointment should make the process more thorough and, undoubtedly, leave no stone unturned.
'Who is to say that in showing the company's wares, a bidder does not emerge for the whole company?'

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